Despite available research, the long-term effects. Some changes are PERMANENT and won't go away, even if you decide to stop taking testosterone. Earlier observational studies suggested that long-term use of testosterone could increase the risk of cardiovascular disease. Testosterone is also known to stimulate the growth of prostate cancer in men who have been diagnosed with this condition.
Recent clinical trials, which provide more accurate information compared to observational studies, have provided some peace of mind regarding the risks of heart and prostate cancer. For men who are clearly deficient in testosterone, there is no apparent increased risk of having a heart attack or stroke or of developing a new prostate cancer from testosterone replacement therapy. In addition, some research shows that testosterone therapy may increase the risk of heart disease. The above results require a well-designed study that records the time needed to restore androgen-dependent function with optimal circulating testosterone for that specific androgen-dependent function.
androgens. While some men believe they feel younger and more vigorous if they take testosterone medications, there is little evidence to support the use of testosterone in otherwise healthy men. Obviously, these effects are directly related to testosterone and not to its flavoring product E2, as was later confirmed in a placebo-controlled trial in which an aromatase inhibitor was combined with the administration of testosterone in hypogonadal men. It can be concluded that the effects of testosterone on muscle strength are demonstrable after 12 to 20 weeks and that, depending on the testosterone levels achieved, the maximum effects are obtained after 6 or 12 months.
The results of this study may help inform doctors and patients about the effects of long-term use of testosterone. The average range of changes observed in the selected measurable outcomes of administering testosterone to hypogonadal men in the reviewed studies. The effects on sexual interest appear after 3 weeks and stabilize after 6 weeks, with no further increases expected. Testosterone is usually given as an injection, also called an injection, or through a gel or patch that is applied to the skin. It is important to have information about when an effect can be expected and when its maximum has been reached. Almost all of these studies were not specifically designed to address the onset or temporary dependence of the effects of testosterone; however, several controlled studies with a different design and scheduled follow-up allow for a reasonable estimate.
Testosterone products are prescribed to men for a variety of potential health benefits, but the causal effects are not clear. While the effects of testosterone have been described in detail, relatively little attention has been paid to how long it takes for these effects to occur and achieve full expression. Studies investigating the effects of testosterone should take this period into account when designing the duration of studies in order to have quantifiable measurements. He investigated the effects of naturally produced testosterone through Mendelian randomization, which mimics randomized trials by taking advantage of the fact that parents randomly transmit their unique genetic variants to their children at the time of conception.
He studied the long-term effects of testosterone in 22 diseases previously explored in randomized controlled trials and hundreds of other traits and diseases that have not yet been explored. investigated in no randomized controlled trial.
